Inland Empire Waterkeeper is a grassroots, non-profit water quality organization with a mission to enhance and protect the quality of the waterways within the Upper Santa Ana River Watershed. This is accomplished through five program tenets: advocacy, education, research, restoration, and enforcement. Established in 2005, Inland Empire Waterkeeper is a chapter of Orange County Coastkeeper, which oversees the Orange County portion of the watershed, and is a separately licensed member of the international Waterkeeper Alliance.

Inland Empire Waterkeeper's vision is to achieve a sustainable watershed free of pollution and a community of motivated water stewards to ensure swimmable, drinkable, fishable waters within the Upper Santa Ana River Watershed.